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Modafinil (as well as armodafinil) belongs to Eugeroics – wakefulness promoting agents; modafinil increases alertness, particularly in sleep deprived individuals, and was noted to facilitate reasoning and problem solving in a systematic review. They are clinically prescribed for narcolepsy, shift work sleep disorder, and daytime sleepiness remaining after sleep apnea treatments.
Modafin is a wakefulness-promoting agent (or eugeroic) used for treatment of excessive daytime sleepiness associated with obstructive sleep apnea, for increase alertness, wakefulness, and vigilance in individuals suffering from sleep disorders such as narcolepsy or shift work disorder. It is also known to boost mental performance, concentration span and attention. It has also seen widespread off-label use as a purported cognition-enhancing agent. In English-speaking countries it is sold under the brand names Alertec, Armodafinil, Nuvigil, Eugeroic, Modavigil, and Provigil.
Possible misspellings: Madafinil, Modafinal.
Modafin is known as Alpha Pharma labeled version of Provigil (Modafinil). As Provigil gets extremely costly – the non-generic form of Modafinil – Modafin has become increasingly popular.
Modafin is used for increase alertness, wakefulness, and vigilance in individuals suffering from sleep disorders such as narcolepsy or shift work disorder. It is also known to boost mental performance, concentration span and attention.
This medication can be considered a good alternative to caffeine pills and other stimulants for people who want to stay awake during working hours.
Modafinil has also found off-label use with the neurological fatigue reported by some with multiple sclerosis. In 2000, Cephalon conducted a study to evaluate modafinil as a potential treatment for MS-related fatigue. A group of 72 people with MS of varying degrees of severity tested two different doses of modafinil and an inactive placebo over nine weeks. Fatigue levels were self-evaluated on standardized scales. Participants taking a lower dose of modafinil reported feeling less fatigued and there was a statistically significant difference in fatigue scores for the lower dose versus the placebo. The higher dose of modafinil was not reported to be significantly more effective.
Modafinil is also used off-label to treat sedation and fatigue in many conditions, including depression, fibromyalgia, chronic fatigue syndrome, myotonic dystrophy, opioid-induced sleepiness, spastic cerebral palsy, and Parkinson’s disease. Modafinil has been shown to improve excessive daytime somnolence and fatigue in primary biliary cirrhosis.
Although the mechanism of action of modafinil was initially unknown, it now appears that the drug acts as a selective, relatively weak, atypical dopamine reuptake inhibitor. However, it appears that other additional mechanisms may also be at play.
Militaries of several countries are known to have expressed interest in modafinil as an alternative to amphetamine—the drug traditionally employed in combat situations where troops face sleep deprivation, such as during lengthy missions. The French government indicated that the Foreign Legion used modafinil during certain covert operations. The United Kingdom’s Ministry of Defence commissioned research into modafinil from QinetiQ and spent £300,000 on one investigation. In 2011, the Indian Air Force announced that modafinil was included in contingency plans.
In the United States military, modafinil has been approved for use on certain Air Force missions, and it is being investigated for other uses. As of November 2012, modafinil is the only drug approved by the Air Force as a “go pill” for fatigue management. The use of dextroamphetamine (a.k.a., Dexedrine) is no longer approved.
The Canadian Medical Association Journal also reports that modafinil is used by astronauts on long-term missions aboard the International Space Station. Modafinil is “available to crew to optimize performance while fatigued” and helps with the disruptions in circadian rhythms and with the reduced quality of sleep astronauts experience.
Modafin side effects
According to documentation distributed by Teva Pharmaceuticals, one-third of participants in clinical trials reported experiencing headaches; 11% reported nausea; other negative side-effects such as nervousness, diarrhea, insomnia, anxiety, dizziness, and gastrointestinal problems were reported by less than 10% of participants.
Rare occurrences have been reported of more serious adverse effects, including severe skin rashes and other symptoms that are probably allergy-related. From the date of initial marketing, December 1998, to January 30, 2007, the US Food and Drug Administration received six cases of severe cutaneous adverse reactions associated with modafinil, including erythema multiforme (EM), Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and DRESS syndrome, involving adult and pediatric patients. The FDA issued a relevant alert. In the same alert, the FDA also noted that angioedema and multi-organ hypersensitivity reactions have also been reported in postmarketing experiences. In 2007, the FDA ordered Cephalon to modify the Provigil leaflet in bold-face print of several serious and potentially fatal conditions attributed to modafinil use, including TEN, DRESS syndrome, and SJS.
The long term safety and effectiveness of modafinil have not been determined.
Modafinil may have an adverse effect on hormonal contraceptives for up to a month after discontinuation.
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Modafin is widely known as Modafinil, Provigil
Other alternative names for Modafin (Modafinil): Alpha-Pharma Healthcare Modafinil, Alpha Pharma Modafinil, Modafinil 200mg 30 pills, Modafin 200mg 30 pills.
All of these are different brands of the same active substance – Modafinil
ModafinTM – Modafinil
Known under the names
Modafin, Modafinil, Alertec, Modavigil, Modiodal, Provigil, Modalert, Modafinilcat, Modiwake.
Modafin is indicated for treatment of narcolepsy as well as sleep disorders and attention deficit disorders (ADD/ADHD).
Each carton contains 3 strips of 10 tablets each.
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